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January 1, 1985Journal of Cardiovascular Pharmacology

Captopril in Hypertension

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Why the study?

Is captopril safe and effective for long-term treatment of hypertension in a real-world setting?

Population

6,737 hypertensive patients, mean entry blood pressure 183/111 mm Hg, 29% with impaired renal function.

Design

Cohort

Follow-up

at least 1 year (for 3,219 patients)

Authors

AJAlan C. JenkinsUniversity of FloridaGDGerald R. DreslinskiOchsner Medical CenterSTS S TadrosAtkins (United States)

Discussion

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Implication

Supports real-world captopril tolerability at ~150 mg/day; leaves open randomized confirmation of long-term efficacy and safety.

Key Points

  • To assess the long-term antihypertensive efficacy and safety profile of modified captopril dosing regimens in clinical practice.
  • Conducted a worldwide postmarketing surveillance study enrolling 6,737 hypertensive patients, of whom 3,219 received captopril for at least 1 year.
  • Included patients with a mean baseline blood pressure of 183 (± 31)/111 (± 16) mm Hg taking an average of 2.3 antihypertensive drugs, with 29% presenting with impaired renal function (serum creatinine ≥ 1.6 mg/dl).
  • Evaluated lower daily dosing strategies combined with longer titration intervals and earlier diuretic co-administration.
  • Maintained long-term blood pressure control with an average captopril dose of approximately 150 mg/day, either as monotherapy or combined with a diuretic.
  • Observed a 12-month cumulative drug discontinuation rate of 5.8% due to adverse reactions.
  • Documented beneficial effects on renal function, establishing an overall safety profile comparable to commonly used antihypertensive agents.

Structured PICO

Is captopril safe and effective for long-term treatment of hypertension in a real-world setting?

P
Population
6,737 hypertensive patients, mean entry blood pressure 183/111 mm Hg, 29% with impaired renal function.
I
Intervention
Captopril (mean dose approximately 150 mg/day) as monotherapy or with a diuretic.
O
Outcome
Long-term antihypertensive efficacy and safety (drug discontinuation due to adverse reactions).safety

A worldwide postmarketing surveillance study demonstrated that captopril at ~150 mg/day is effective and safe for long-term hypertension management, with a low rate of discontinuation due to adverse events.

Cite This Study

Jenkins et al. (1985) studied this question.

synapsesocial.com/papers/6a7161fa31a3df82432991achttps://doi.org/10.1097/00005344-198507001-00019

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and Efficacy of Chronic Therapy with Captopril in Hypertensive Patients: An Update1981 · 35 citations
  2. 2Long-term antihypertensive therapy with captopril.1983 · 49 citations
  3. 3Captopril, an Orally Active Converting Enzyme Inhibitor, in the Treatment of Primary Hypertension1981 · 14 citations
  4. 4Efficacy, Safety, and Quality-of-Life Assessment of Captopril Antihypertensive Therapy in Clinical Practice1990 · 21 citations
  5. 5Review of the Overall Experience of Captopril in Hypertension1984 · 112 citations