Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1982Clinical Science

Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does captopril, alone or in combination with hydrochlorothiazide, reduce blood pressure in men with mild to moderate hypertension?

Population

475 men with mild to moderate hypertension (diastolic blood pressure 92-109 mmHg)

Comparison

Captopril for 7 weeks, followed by captopril… vs Placebo for 7 weeks, followed by…

Design

RCT, Randomized

Follow-up

14 weeks

Discussion

Loading...

Member takes

Implication

Supports captopril, alone or combined, for BP control in mild-moderate hypertension; extends foundational RCT evidence for ACE inhibitors.

Key Points

  • To assess the efficacy and safety of low-dose, twice-daily captopril regimens alone and in combination with hydrochlorothiazide for mild to moderate hypertension.
  • Randomized trial of 475 men with diastolic blood pressure between 92 and 109 mmHg assigned to placebo or captopril (37.5, 75, or 150 mg/day) for 7 weeks.
  • Following week 7, placebo recipients and two-thirds of captopril-treated participants received hydrochlorothiazide (25 mg twice daily) for a further 7 weeks.
  • At 7 weeks, captopril reduced blood pressure by 12.2 ± 0.8 / 9.4 ± 0.4 mmHg (n = 323) compared to 20 ± 1.7 / 3.4 ± 0.8 mmHg with placebo (n = 76).
  • At 14 weeks, captopril plus hydrochlorothiazide lowered blood pressure by 24.4 ± 1.1 / 16.2 ± 0.6 mmHg (n = 173) versus 10.3 ± 1.9 / 10.2 ± 0.9 mmHg for captopril plus placebo (n = 83), with low doses performing similarly to high doses.
  • Treatment discontinuation due to adverse effects occurred in 3.9% of patients (15 of 384).

Structured PICO

Does captopril, alone or in combination with hydrochlorothiazide, reduce blood pressure in men with mild to moderate hypertension?

P
Population
475 men with mild to moderate hypertension (diastolic blood pressure 92-109 mmHg)
I
Intervention
Captopril (37.5, 75, or 150 mg/day) for 7 weeks, followed by captopril alone or captopril plus hydrochlorothiazide (25 mg twice daily) for 7 additional weeks
C
Comparator
Placebo for 7 weeks, followed by hydrochlorothiazide (25 mg twice daily) for 7 additional weeks
O
Outcome
Reduction in blood pressuresurrogate

Low-dose captopril, alone or in combination with hydrochlorothiazide, effectively reduces blood pressure in men with mild to moderate hypertension with a low rate of adverse effects.

Limitations

  • Monitoring studies are needed to confirm the equality of twice-daily versus thrice-daily treatment

Cite This Study

A 1982 study studied this question.

synapsesocial.com/papers/6a8983c01fb56efa37d45506https://doi.org/10.1042/cs063443s
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low-Dose Captopril for the Treatment of Mild to Moderate Hypertension1984 · 119 citations
  2. 2Low-dose captopril for the treatment of mild to moderate hypertension. I. Results of a 14-week trial. Veterans Administration Cooperative Study Group on Antihypertensive Agents1984 · 85 citations
  3. 3Racial differences in response to low‐dose captopril are abolished by the addition of hydrochlorothiazide.1982 · 56 citations
  4. 4Low-Dose Captopril1982 · 30 citations
  5. 5Low-dose captopril for the treatment of mild to moderate hypertension.1983 · 22 citations