What question did this study set out to answer?

To evaluate the effectiveness of low-dose captopril in treating mild to moderate hypertension.

October 1, 1984Archives of Internal Medicine

Low-Dose Captopril for the Treatment of Mild to Moderate Hypertension

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Why the study?

Does low-dose captopril reduce blood pressure in men with uncomplicated mild to moderate hypertension?

Population

495 men with uncomplicated mild to moderate hypertension (diastolic BP 92 to 109 mm Hg)

Comparison

Captopril at dosages of 12.5 mg three times a… vs Placebo three times a day for 7 weeks, with…

Design

RCT, Randomized to one of five regimens

Follow-up

14 weeks

Discussion

Member takes

Implication

Supports low-dose captopril initiation in mild-moderate hypertension; confirms equivalent efficacy to higher doses with additive diuretic benefit.

Key Points

To evaluate the effectiveness of low-dose captopril in treating mild to moderate hypertension.
Randomized trial with 495 men having uncomplicated hypertension, diastolic BP 92 to 109 mm Hg.
Participants received one of five captopril regimens or placebo for seven weeks.
Blood pressure response assessed with and without hydrochlorothiazide added for an additional seven weeks.
Captopril reduced blood pressure by 10.2 to 14.2/8.6 to 10.5 mm Hg compared to placebo.
Combination of hydrochlorothiazide and captopril decreased blood pressure by 24.9 to 26.4/14.4 to 17.3 mm Hg.
Captopril at 37.5 mg/day was as effective as 150 mg/day, indicating a lower initial dosing may suffice.

Structured PICO

Does low-dose captopril reduce blood pressure in men with uncomplicated mild to moderate hypertension?

Population

495 men with uncomplicated mild to moderate hypertension (diastolic BP 92 to 109 mm Hg)

Intervention

Captopril at dosages of 12.5 mg three times a day, 25 mg three times a day, 37.5 mg twice daily, or 50 mg three times a day for 7 weeks, with hydrochlorothiazide 25 mg twice daily added to two-thirds of patients for an additional 7 weeks

Comparator

Placebo three times a day for 7 weeks, with hydrochlorothiazide 25 mg twice daily added for an additional 7 weeks

Outcome

Blood pressure reductionsurrogate

Low-dose captopril (37.5 mg/day) is as effective as higher doses for treating uncomplicated hypertension, and its antihypertensive effect is greatly enhanced by the addition of hydrochlorothiazide.

Cite This Study

A 1984 study studied this question.

synapsesocial.com/papers/6a71999a75498292b70b070b https://doi.org/10.1001/archinte.1984.04400010055010

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Implication

Supports low-dose captopril initiation in mild-moderate hypertension; confirms equivalent efficacy to higher doses with additive diuretic benefit.

Low-Dose Captopril for the Treatment of Mild to Moderate Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Low-Dose Captopril for the Treatment of Mild to Moderate Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider