Why the study?
Does low-dose captopril reduce diastolic blood pressure in patients with mild to moderate hypertension?
Population
140 patients with mild to moderate hypertension
Comparison
Captopril at doses of 12.5 mg, 25 mg, 37.5 mg… vs Hydrochlorothiazide alone or different doses of…
Design
RCT, double-blind
Follow-up
7.8 to 9.5 months
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Supports captopril-hydrochlorothiazide combination for greater DBP reduction; extends evidence for ACEI-diuretic synergy in mild-moderate hypertension.
Does low-dose captopril reduce diastolic blood pressure in patients with mild to moderate hypertension?
Low-dose captopril, particularly when combined with hydrochlorothiazide, provides sustained and effective long-term reduction in diastolic blood pressure for patients with mild to moderate hypertension.
A 1983 study studied this question.
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