Key result
Low-dose captopril (25 mg three times a day) combined with hydrochlorothiazide reduced mean seated diastolic blood pressure to 90 +/- 6 mm Hg compared to 103 +/- 5 mm Hg on placebo.
Why the study?
Does low-dose captopril (alone or combined with hydrochlorothiazide) reduce seated diastolic blood pressure in patients with mild to moderate essential hypertension previously uncontrolled by hydrochlorothiazide?
Does low-dose captopril (alone or combined with hydrochlorothiazide) reduce seated diastolic blood pressure in patients with mild to moderate essential hypertension previously uncontrolled by hydrochlorothiazide?
Absolute Event Rate: 96% vs 103%
Low-dose captopril combined with a diuretic effectively reduces diastolic blood pressure in patients with mild to moderate essential hypertension and may be better tolerated than higher doses.
May support low-dose captopril plus diuretic for mild hypertension; small observational cohort leaves open confirmation in randomized trials.
The effect of low doses (25 mg three times a day) of captopril was evaluated in 16 patients with mild to moderate essential hypertension, previously uncontrolled by hydrochlorothiazide. After a no-treatment period, mean eight-hour seated diastolic blood pressure (SDBP, mm Hg) was 103 +/- 5 on placebo, 95 +/- 8 after a single dose of captopril, 96 +/- 4 after two weeks of captopril alone, and 90 +/- 6 after its combination with hydrochlorothiazide. Though nine patients had at least a 10% fall in SDBP after the initial dose of captopril, only three had a comparable fall after two weeks; after captopril and hydrochlorothiazide, however, 12 patients had such a response. Captopril decreased mean angiotensin-converting enzyme activity and plasma aldosterone, though to a lesser extent with continued therapy. Because its side effects appear dose related, low doses of captopril combined with a diuretic are effective and may be better tolerated.
No takes yet. Share an insight, caveat, or question.
Peter H. Vlasses (1982) studied mild to moderate essential hypertension (n=16). Captopril vs. Placebo was evaluated on mean eight-hour seated diastolic blood pressure (SDBP, mm Hg). Low-dose captopril (25 mg three times a day) combined with hydrochlorothiazide reduced mean seated diastolic blood pressure to 90 +/- 6 mm Hg compared to 103 +/- 5 mm Hg on placebo.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: