Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1983Hypertension

Long-term antihypertensive therapy with captopril.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does long-term captopril therapy safely maintain blood pressure control in hypertensive patients?

Population

7,103 hypertensive patients participating in various investigational studies, including 4,397 treated for 3…

Design

Cohort

Follow-up

3 months to 4 years

Authors

JGJ T GroelSTS S TadrosAtkins (United States)GDGerald R. DreslinskiOchsner Medical Center

Discussion

Loading...

Member takes

Implication

Supports captopril tolerability in hypertension cohorts; leaves open randomized confirmation of sustained efficacy and safety.

Structured PICO

Does long-term captopril therapy safely maintain blood pressure control in hypertensive patients?

P
Population
7,103 hypertensive patients participating in various investigational studies, including 4,397 treated for 3 months to 4 years (2,498 with mild or moderate essential hypertension, 893 with severe essential hypertension, and 517 with renovascular hypertension).
I
Intervention
Captopril (majority also receiving a diuretic) administered for up to 4 years.
O
Outcome
Continuing effectiveness (blood pressure control) and safety (side-effects and drug discontinuance).safety

Long-term captopril therapy provides sustained blood pressure control and is generally well-tolerated, with an acceptable safety profile over up to 4 years of treatment.

Cite This Study

Groel et al. (1983) studied this question.

synapsesocial.com/papers/6a7708356789de8d0af6f533https://doi.org/10.1161/01.hyp.5.5_pt_2.iii145

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long‐term efficacy of angiotensin‐converting‐enzyme inhibition with captopril in mild‐to‐moderate essential hypertension.1982 · 27 citations
  2. 2Proteinuria During Long-term Captopril Therapy1980 · 101 citations
  3. 3Long‐term experience with captopril in severe hypertension.1982 · 36 citations
  4. 4Long‐term experience of captopril in the treatment of primary (essential) hypertension.1982 · 16 citations
  5. 5Safety and Efficacy of Chronic Therapy with Captopril in Hypertensive Patients: An Update1981 · 35 citations