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November 12, 1981The Journal of Clinical Pharmacology

Safety and Efficacy of Chronic Therapy with Captopril in Hypertensive Patients: An Update

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Why the study?

What is the safety and efficacy of chronic captopril therapy in patients with clinical hypertension?

Population

81 patients with different types of clinical hypertension, mostly previously uncontrollable high blood…

Design

Cohort

Follow-up

2 years

Authors

BWBernard WaeberPreventive CardiologyHBHans R. BrunnerGeneral / Preventive / LipidsHGHaralambos GavrasGeneral / Preventive / Lipids

Discussion

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Implication

Captopril adverse effects were frequent in hypertension and increased with renal impairment; supports renal dose adjustment but leaves optimal regimens open to prospective trials.

Structured PICO

What is the safety and efficacy of chronic captopril therapy in patients with clinical hypertension?

P
Population
81 patients with different types of clinical hypertension, mostly previously uncontrollable high blood pressure.
I
Intervention
Captopril (chronic therapy, up to 2 years)
O
Outcome
Blood pressure control and incidence of side effectssafety

Early clinical experience with captopril for severe hypertension revealed a high rate of adverse effects (46.9%), suggesting the need for lower, renally-adjusted dosing.

Cite This Study

Waeber et al. (1981) studied this question.

synapsesocial.com/papers/6a8bcbc790fae8fd47e993c9https://doi.org/10.1002/j.1552-4604.1981.tb05658.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients1979 · 356 citations
  2. 2Effect of Captopril on Renal Vascular Tone in Patients with Essential Hypertension1979 · 63 citations
  3. 3Proteinuria During Long-term Captopril Therapy1980 · 101 citations
  4. 4Increased Glomerular Filtration Rate after Converting-Enzyme Inhibition in Essential Hypertension1979 · 136 citations
  5. 5Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man1978 · 604 citations