Key result
Valsartan alone or combined with enalapril at non-hypotensive doses improved survival (67-85%) compared to untreated animals (37%) or enalapril alone (55%) in spontaneously hypertensive rats.
Why the study?
Does valsartan alone or in combination with enalapril improve survival in spontaneously hypertensive rats with endothelial dysfunction?
Population
Spontaneously hypertensive rats treated with inhibitors of nitric oxide synthase to induce endothelial…
Comparison
Valsartan alone or in combination with enalapril… vs Untreated animals or enalapril alone
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change clinical practice; hypothesis-generating for non-hypotensive ARB or ARB-ACEI regimens in hypertensive models.
Does valsartan alone or in combination with enalapril improve survival in spontaneously hypertensive rats with endothelial dysfunction?
In a rat model of endothelial dysfunction, non-hypotensive doses of valsartan, alone or with enalapril, improved survival despite no improvement in histological appearance or kidney function.
Gasparo et al. (2000) studied Hypertension with endothelial dysfunction. Valsartan alone or in combination with enalapril vs. Untreated animals or enalapril alone was evaluated on Survival rates. Valsartan alone or combined with enalapril at non-hypotensive doses improved survival (67-85%) compared to untreated animals (37%) or enalapril alone (55%) in spontaneously hypertensive rats.
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