Key result
Long-term renin-angiotensin system inhibition with enalapril or losartan significantly protected cardiovascular structure and prolonged life span in normal rats compared with untreated controls.
Why the study?
Does long-term RAS inhibition with enalapril or losartan prevent cardiovascular aging and prolong life span in normal rats?
Population
Normal rats, treatment initiated 2 weeks after weaning
Comparison
Enalapril or losartan vs Untreated control group
Design
Preclinical
Follow-up
Up to spontaneous death (or 18 months)
Authors
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Hypothesis-generating in healthy rat models; leaves open translation to human cardiovascular aging or longevity.
Does long-term RAS inhibition with enalapril or losartan prevent cardiovascular aging and prolong life span in normal rats?
Long-term RAS inhibition with either an ACE inhibitor or ARB prevents age-related cardiovascular deterioration and prolongs life span in normal rats.
Basso et al. (2007) studied Normal rats. Enalapril or losartan vs. Untreated control was evaluated on Cardiovascular structure and function, and life span. Long-term renin-angiotensin system inhibition with enalapril or losartan significantly protected cardiovascular structure and prolonged life span in normal rats compared with untreated controls.
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