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July 7, 2007AJP Heart and Circulatory Physiology

Long-term AT1receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats

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Why the study?

Does L-158,809 improve metabolic function and provide renoprotection in aging male Fischer-344 rats?

Population

Male Fischer-344 (F344) rats, n=21 (young n=8, older control n=7, older treated n=6)

Comparison

L-158,809 orally for 1 year vs Untreated older control rats

Design

Preclinical

Follow-up

1 year

Authors

SGShea Gilliam‐DavisVPValerie PayneSKSherry O. Kasper

Discussion

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Overview

Hypothesis-generating for AT1 blockade in age-related renal injury; leaves open human translation and does not alter practice.

Structured PICO

Does L-158,809 improve metabolic function and provide renoprotection in aging male Fischer-344 rats?

P
Population
Male Fischer-344 (F344) rats, n=21 (young n=8, older control n=7, older treated n=6)
I
Intervention
L-158,809 (AT1 receptor blocker) orally (20 mg/l) for 1 year
C
Comparator
Untreated older control rats
O
Outcome
Plasma and urinary ANG peptide levels, systolic blood pressure (SBP), and indexes of glucose metabolismsurrogate

Long-term AT1 receptor blockade prevents age-related insulin resistance and renal injury in normotensive rats.

Cite This Study

Gilliam‐Davis et al. (2007) studied this question.

synapsesocial.com/papers/6a6fc355ac440176ef286d44https://doi.org/10.1152/ajpheart.00457.2007
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