Key result
Enalapril and losartan delayed age-related cardiac hypertrophy and aortic growth and raised aortic endothelium nitric oxide synthase activity in normal rats over 6 to 18 months.
Why the study?
Does chronic angiotensin II inhibition with enalapril or losartan delay cardiovascular damage and affect NOS activity in normal rats during aging?
Population
Normal rats treated since weaning
Comparison
Enalapril 10 mg/kg per day or Losartan 10 mg/kg… vs Untreated control rats
Design
Preclinical
Follow-up
6 or 18 months
Authors
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May attenuate age-related CV changes in rat models; leaves open human translation.
Does chronic angiotensin II inhibition with enalapril or losartan delay cardiovascular damage and affect NOS activity in normal rats during aging?
p-value: p=<0.05
Chronic angiotensin II inhibition with enalapril or losartan delays age-related cardiac hypertrophy and aortic growth while increasing aortic endothelium NOS activity in normal rats.
Bosc et al. (2001) studied Normal aging. Enalapril or Losartan vs. Control (untreated) was evaluated on Systolic blood pressure, cardiac/left ventricular/aortic weight, and nitric oxide synthase (NOS) activity (p=<0.05). Enalapril and losartan delayed age-related cardiac hypertrophy and aortic growth and raised aortic endothelium nitric oxide synthase activity in normal rats over 6 to 18 months.