Why the study?
Does lisinopril or losartan prevent angiotensin II-induced myocyte necrosis and coronary vascular damage in rats?
Population
54 rats, including unoperated controls, rats with renovascular hypertension, and rats with continuous…
Comparison
Lisinopril or losartan started one day before… vs Untreated renovascular hypertension, untreated…
Design
Preclinical
Follow-up
14 days
Authors
Loading...
Does not support practice change; leaves open translation of AT1-mediated cardioprotection from rat models to humans.
Does lisinopril or losartan prevent angiotensin II-induced myocyte necrosis and coronary vascular damage in rats?
Angiotensin II-induced cardiomyocyte necrosis and coronary vascular damage are AT1 receptor-mediated and can be prevented by losartan or dose-dependently by lisinopril.
Kabour et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: