Why the study?
Does co-administration of losartan and SB 209670 reduce blood pressure and improve vasodilation in hypertensive transgenic rats compared to either agent alone?
Population
Hypertensive transgenic (TGR27) rats and normotensive Sprague-Dawley control strain, along with other…
Comparison
Losartan, endothelin antagonist SB 209670, or… vs Saline infusion.
Design
Preclinical
Follow-up
8 hours
Authors
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No immediate clinical implications; leaves open whether dual AT1/ET blockade enhances BP control in renin-dependent hypertension.
Does co-administration of losartan and SB 209670 reduce blood pressure and improve vasodilation in hypertensive transgenic rats compared to either agent alone?
The maintenance of hypertension in TGR(mRen-2)27 rats is dependent upon widespread vasoconstriction mediated by both angiotensin II and endothelin.
Gardiner et al. (1995) studied this question.
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