Why the study?
Does losartan reduce renal endothelin-1 production independently of blood pressure reduction in hypertensive uremic rats?
Population
Hypertensive uremic rats with reduced renal mass
Comparison
Losartan (20 mg/kg per day) for 6 weeks vs Conventional triple therapy, untreated uremic…
Design
Preclinical
Follow-up
6 weeks
Authors
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Losartan may confer BP-independent renoprotection in experimental uremia; leaves open translation to human CKD management.
Does losartan reduce renal endothelin-1 production independently of blood pressure reduction in hypertensive uremic rats?
Losartan provides renal protective effects in hypertensive uremic rats by reducing renal endothelin-1 production through tissue-specific AT1 receptor blockade, independent of its blood pressure-lowering effects.
Dumont et al. (2001) studied this question.
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