Why the study?
Does losartan or captopril reduce endothelin-1 production in rats with reduced renal mass?
Population
Rats with reduced renal mass and sham-operated controls
Comparison
Losartan or captopril for 6 weeks vs Untreated uremic rats and untreated…
Design
Preclinical
Follow-up
6 weeks
Authors
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May indicate AT1-specific ET-1 effects beyond ACE inhibition in experimental CKD; leaves open relevance to human therapy.
Does losartan or captopril reduce endothelin-1 production in rats with reduced renal mass?
In a rat model of chronic renal failure, the AT1 antagonist losartan, but not the ACE inhibitor captopril, attenuated Ang II-induced ET-1 production in glomeruli.
Larivière et al. (1998) studied this question.
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