Key result
Prolonged treatment with losartan or captopril significantly reduced blood pressure and decreased endothelial dysfunction in aortic rings from spontaneously hypertensive rats.
Why the study?
Does prolonged treatment with losartan improve endothelial dysfunction in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR) aged 16 weeks
Comparison
Losartan 10 mg/kg per day administered via… vs Captopril 60 mg/kg per day administered via…
Design
Preclinical
Follow-up
12 weeks
Authors
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Does not alter human hypertension care; hypothesis-generating for angiotensin II in endothelial dysfunction.
Does prolonged treatment with losartan improve endothelial dysfunction in spontaneously hypertensive rats?
Prolonged treatment with losartan or captopril improves endothelial dysfunction in spontaneously hypertensive rats, confirming the role of endothelium-derived contracting factors and angiotensin II in vascular dysfunction.
Rodrigo et al. (1997) studied Hypertension. Losartan vs. Captopril (60 mg/kg per day) was evaluated on Blood pressure and vascular reactivity in aortic rings. Prolonged treatment with losartan or captopril significantly reduced blood pressure and decreased endothelial dysfunction in aortic rings from spontaneously hypertensive rats.
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