Why the study?
Does losartan reduce constrictor responses to endothelin-1 and U46619 in aortic rings from spontaneously hypertensive rats?
Population
Aortic rings from spontaneously hypertensive rats (SHR)
Comparison
Losartan (10 mol/l) pre-incubation, with or… vs Control aortic rings without losartan
Design
Preclinical
Authors
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Losartan may attenuate vasoconstriction via nitric oxide in hypertensive rat aortas; hypothesis-generating and should not change clinical practice.
Does losartan reduce constrictor responses to endothelin-1 and U46619 in aortic rings from spontaneously hypertensive rats?
Losartan reduces vasoconstriction induced by endothelin-1 and a thromboxane A2 analogue in SHR aortic rings, an effect that appears to be mediated by nitric oxide.
Maeso et al. (1997) studied this question.
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