Why the study?
Does losartan inhibit contractile responses in rat conductance and resistance arteries?
Population
Segments of small mesenteric arteries and rings of aorta from rats
Comparison
Losartan, CGP 42112A, DuP 532, and EXP 3174 vs Contractile responses without antagonist
Design
Preclinical
Authors
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Confirms AT1 selectivity at nanomolar concentrations in rat arteries; leaves open potential TP receptor antagonism at higher doses.
Does losartan inhibit contractile responses in rat conductance and resistance arteries?
Losartan selectively blocks AT1 receptors at nanomolar concentrations and may block vascular TP receptors at micromolar concentrations in rat arteries.
Corriu et al. (1995) studied this question.
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