Why the study?
Does losartan alter sympathetically mediated vasoconstriction in healthy volunteers?
Population
7 healthy, normotensive volunteers, age 21-32 years
Comparison
Losartan 50 mg orally administered for a 6-week… vs Placebo for a 6-week treatment period
Design
Observer blind
Follow-up
6 weeks per treatment period
Authors
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Does not support altering losartan use in patients; hypothesis-generating for AT1-independent sympathetic vasoconstriction by angiotensin II.
Does losartan alter sympathetically mediated vasoconstriction in healthy volunteers?
Losartan enhances locally mediated sympathetic vasoconstriction in the forearm circulation of healthy volunteers, suggesting the adrenergic sympathetic constrictor action of angiotensin II is not mediated by the AT1 receptor.
Lyons et al. (2006) studied this question.
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