Why the study?
Does losartan reduce sympathetic vascular responses in spontaneously hypertensive rats?
Population
Pithed spontaneously hypertensive rats (SHR)
Design
Preclinical
Follow-up
8 days
Authors
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Losartan may inhibit sympathetic vascular responses in hypertensive rat models; leaves open translation to human hypertension therapy.
Does losartan reduce sympathetic vascular responses in spontaneously hypertensive rats?
Losartan demonstrates prejunctional sympathoinhibitory effects on vascular responses, particularly in the kidney, in spontaneously hypertensive rats.
Moreau et al. (1993) studied this question.
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