Why the study?
Does losartan inhibit Angiotensin II-induced vasoconstriction in the forearm vascular bed of healthy volunteers?
Population
24 healthy, sodium-replete subjects
Comparison
Losartan administered intra-arterially or orally vs Baseline (before losartan administration)
Follow-up
5 days (for oral administration)
Authors
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Losartan inhibits Ang II vasoconstriction in healthy forearm; leaves open translation to clinical outcomes in disease.
Does losartan inhibit Angiotensin II-induced vasoconstriction in the forearm vascular bed of healthy volunteers?
Both intra-arterial and oral losartan significantly inhibit Angiotensin II-induced vasoconstriction in the human forearm vascular bed, with oral administration being more potent likely due to the formation of its active metabolite.
Baan et al. (1996) studied this question.
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