Key result
Losartan pretreatment (50 mg/day) did not alter baseline alpha-adrenoceptor-mediated vasoconstriction (log[ED50] 2.68 vs 2.69) but attenuated the enhanced response induced by exogenous Ang II.
Why the study?
Does losartan influence alpha-adrenoceptor-mediated vasoconstrictor response in healthy men?
Population
9 healthy men
Comparison
Losartan 50 mg/day oral for 3 days, with and… vs Control (without losartan pretreatment)
Follow-up
3 days
Authors
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Losartan may selectively blunt Ang II-enhanced alpha responses without affecting baseline vasoconstriction in healthy men; hypothesis-generating for vascular interactions.
Does losartan influence alpha-adrenoceptor-mediated vasoconstrictor response in healthy men?
Absolute Event Rate: 2.68% vs 2.69%
Losartan does not directly affect alpha-adrenoceptor-mediated vasoconstriction but attenuates the enhancement of this response by exogenous Angiotensin II in healthy men.
Harada et al. (2000) studied Healthy (n=9). Losartan vs. Without pretreatment (control) was evaluated on Log of the infusion rate of phenylephrine producing half-maximal venoconstriction [log(ED50)]. Losartan pretreatment (50 mg/day) did not alter baseline alpha-adrenoceptor-mediated vasoconstriction (log[ED50] 2.68 vs 2.69) but attenuated the enhanced response induced by exogenous Ang II.
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