Key result
Losartan 100 mg attenuated local venoconstrictor and systemic pressor responses to angiotensin I and II, whereas enalapril 10 mg blocked only responses to angiotensin I.
Why the study?
Does oral losartan or enalapril alter local venous and systemic pressor responses to angiotensin I and II in healthy men?
RCT (n=8)
Double-blind
Does oral losartan or enalapril alter local venous and systemic pressor responses to angiotensin I and II in healthy men?
Losartan directly antagonizes angiotensin II receptors to attenuate responses to both angiotensin I and II, whereas enalapril only blocks angiotensin I responses via ACE inhibition.
No takes yet. Share an insight, caveat, or question.
Losartan provides broader angiotensin blockade than enalapril; confirms direct AT1 antagonism versus ACE inhibition in humans.
Goldberg et al. (1996) conducted an RCT in Healthy (n=8). Losartan and enalapril vs. Placebo was evaluated on Local venous and systemic pressor responses to angiotensin I and II. Losartan 100 mg attenuated local venoconstrictor and systemic pressor responses to angiotensin I and II, whereas enalapril 10 mg blocked only responses to angiotensin I.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: