Why the study?
Do enalapril and losartan have different effects on forearm vascular responses to angiotensin I, angiotensin II, and bradykinin in healthy men?
Population
8 healthy men
Comparison
Enalapril, losartan, and losartan given orally… vs Placebo given on a separate occasion
Design
RCT, randomised, 4-period crossover study, double-blind
Follow-up
4-6 h after dosing
Authors
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ACEI/ARB selection may consider bradykinin effects in relevant patients; confirms distinct vascular mechanisms in humans.
Do enalapril and losartan have different effects on forearm vascular responses to angiotensin I, angiotensin II, and bradykinin in healthy men?
This study demonstrates the distinct mechanistic differences between ACE inhibitors and ARBs in human vasculature, specifically highlighting enalapril's potentiation of bradykinin-induced vasodilation which losartan lacks.
Cockcroft et al. (1993) studied this question.