Why the study?
Does local administration of enalaprilat alter forearm blood flow and vascular responses to angiotensin and bradykinin in healthy men?
Population
24 healthy men
Comparison
Enalaprilat and/or peptide substrates… vs Basal conditions and the non-infused control arm
Design
Other
Authors
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Local enalaprilat does not alter basal forearm tone; leaves open endogenous ACE contributions to resting vascular resistance in health.
Does local administration of enalaprilat alter forearm blood flow and vascular responses to angiotensin and bradykinin in healthy men?
Local ACE inhibition in the human forearm alters vascular responses to exogenous angiotensin I and bradykinin but does not affect basal vascular resistance vessel tone.
Benjamin et al. (1989) studied this question.
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