September 1, 1991Clinical Pharmacology & Therapeutics
Local forearm vasodilation with intra-arterial administration of enalaprilat in humans
Why the study?
Does intra-arterial enalaprilat produce peripheral vasodilation through a local mechanism in normal subjects?
Population
Normal subjects
Comparison
Enalaprilat 2 micrograms/min/dl forearm volume… vs Vehicle
Design
Other
Follow-up
4 minutes
Authors
Discussion
Loading...
Member takes
Implication
Supports local ACE-inhibitor vasodilation in healthy subjects; leaves open relevance to patients and therapeutic outcomes.
Structured PICO
Does intra-arterial enalaprilat produce peripheral vasodilation through a local mechanism in normal subjects?
P
Population
Normal subjects
I
Intervention
Enalaprilat 2 micrograms/min/dl forearm volume (FAV) infused into the brachial artery
C
Comparator
Vehicle
O
Outcome
Changes in forearm blood flow (FBF) measured with strain-gauge plethysmographysurrogate
Intra-arterial enalaprilat produces local peripheral vasodilation in normal subjects, an effect that is independent of circulating renin-angiotensin system inhibition and partially mediated by prostaglandins.
Cite This Study
Bank et al. (1991) studied this question.