Key result
Bilateral intracoronary infusion of enalaprilat significantly increased coronary sinus blood flow (+19%, p<.001) and reduced coronary resistance (-18%, p<.001) in dilated cardiomyopathy.
Why the study?
Does intracoronary enalaprilat improve coronary hemodynamics and left ventricular function in patients with dilated cardiomyopathy?
Population
16 patients with dilated cardiomyopathy and normal coronary arteriograms
Design
Other
Authors
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May suggest role for local ACE inhibition in DCM coronary hemodynamics; leaves open clinical benefit pending randomized trials.
Does intracoronary enalaprilat improve coronary hemodynamics and left ventricular function in patients with dilated cardiomyopathy?
Effect estimate: +19%
Absolute Event Rate: 214% vs 181%
p-value: p=<.001
Intracoronary enalaprilat induces direct coronary vasodilation in patients with dilated cardiomyopathy, independent of its systemic effects.
Foult et al. (1988) studied Dilated cardiomyopathy (n=16). Enalaprilat vs. Baseline was evaluated on Coronary sinus blood flow (ml.min-1) (+19%, p=<.001). Bilateral intracoronary infusion of enalaprilat significantly increased coronary sinus blood flow (+19%, p<.001) and reduced coronary resistance (-18%, p<.001) in dilated cardiomyopathy.
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