What question did this study set out to answer?

To determine whether angiotensin-converting enzyme inhibition by enalaprilat influences coronary vascular tone, sympathetic activity, and myocardial oxygen consumption in conscious dogs.

March 1, 1987Journal of Cardiovascular Pharmacology

Dilation of Epicardial Arteries in Conscious Dogs Induced by Angiotensin-Converting Enzyme Inhibition with Enalaprilat

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Why the study?

Does enalaprilat alter sympathetic activity, myocardial oxygen consumption, and coronary vascular tone in conscious dogs?

Population

Conscious dogs (n=8) evaluated under normal sodium intake and sodium deprivation

Comparison

Enalaprilat vs Control (baseline state)

Design

Preclinical

Authors

JHJ. HoltzUniversity of Pittsburgh Medical Center RBRudi BusseVascular Medicine OSOlaf SommerUniversity of Freiburg

Discussion

Member takes

Implication

Supports coronary effects of enalaprilat in dogs; leaves open translation to human ischemia risk or practice.

Key Points

To determine whether angiotensin-converting enzyme inhibition by enalaprilat influences coronary vascular tone, sympathetic activity, and myocardial oxygen consumption in conscious dogs.
Administered intravenous enalaprilat (0.03 and 0.3 mg/kg over 5-minute infusions at 30-minute intervals) to conscious dogs (n = 8) under normal sodium intake (2–4 mEq/kg/day).
Repeated evaluations after renin-angiotensin activation induced by sodium deprivation (3 doses of 1 mg/kg furosemide plus 7 days of sodium intake below 0.2 mEq/day).
Under normal sodium intake, high-dose enalaprilat decreased myocardial oxygen consumption to 87 ± 2% of control, reduced mean arterial pressure to 90 ± 1%, and increased conduit artery diameter by +3.2 ± 0.7% without altering plasma norepinephrine release rate.
Under sodium deprivation, enalaprilat expanded conduit artery diameter by +4.0 ± 0.9%, increased coronary flow by +45 ± 12%, and reduced mean arterial pressure to 76 ± 6%, while heart rate and norepinephrine release remained stable.

Structured PICO

Does enalaprilat alter sympathetic activity, myocardial oxygen consumption, and coronary vascular tone in conscious dogs?

Population

Conscious dogs (n=8) evaluated under normal sodium intake and sodium deprivation

Intervention

Enalaprilat (0.03 and 0.3 mg/kg i.v. during 5-min infusion with 30-min intervals)

Comparator

Control (baseline state)

Outcome

Sympathetic activity (norepinephrine release rate), myocardial oxygen consumption, and vascular tone in coronary conduit and resistance vesselssurrogate

Enalaprilat dilates epicardial arteries and reduces myocardial oxygen consumption without reflex sympathetic activation, suggesting it is unlikely to provoke myocardial ischemia.

Cite This Study

Holtz et al. (1987) studied this question.

synapsesocial.com/papers/6a7c348205df6d7f2ea15cd9 https://doi.org/10.1097/00005344-198703000-00011

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Dilation of Epicardial Arteries in Conscious Dogs Induced by Angiotensin-Converting Enzyme Inhibition with Enalaprilat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Dilation of Epicardial Arteries in Conscious Dogs Induced by Angiotensin-Converting Enzyme Inhibition with Enalaprilat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider