Why the study?
Does dietary sodium intake (low vs. normal) alter the short-term neurohormonal responses to a single dose of enalapril in healthy dogs?
Population
8 clinically healthy male Beagle dogs
Comparison
Single dose of enalapril after a period of being… vs Single dose of enalapril after a period of being…
Design
Preclinical
Follow-up
24 hours
Authors
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Low-sodium diet may alter acute enalapril responses in dogs; hypothesis-generating for dietary sodium effects on ACE inhibitors.
Does dietary sodium intake (low vs. normal) alter the short-term neurohormonal responses to a single dose of enalapril in healthy dogs?
In healthy dogs, a low-sodium diet alters the acute neurohormonal response to enalapril compared to a normal-sodium diet, suggesting dietary sodium intake may influence ACE inhibitor pharmacodynamics.
Koch et al. (1994) studied this question.
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