What does this research mean for the field?

A novel ACHPA-containing renin inhibitor is as effective as the ACE inhibitor enalaprilat in lowering blood pressure in renin-dependent renovascular hypertension, and both agents similarly reduce renal function during high-renin states, supporting the role of the renin-angiotensin system in maintaining renal function under these conditions. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

February 1, 1987HypertensionOpen Access

Comparison of a new renin inhibitor and enalaprilat in renal hypertensive dogs.

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Why the study?

Does ACHPA-containing renin inhibitory peptide reduce blood pressure similarly to enalaprilat in conscious one-kidney dogs with renal artery constriction?

Population

Conscious one-kidney dogs before and after tightening a renal artery clamp

Comparison

ACHPA-containing renin inhibitory peptide vs Enalaprilat (0.003-0.1 mg/kg i.v. bolus)

Design

Preclinical

Follow-up

14 days

Authors

SSShaler G. SmithMerck & Co., Inc., Rahway, NJ, USA (United States)ASAndrea A. SeymourMerck & Co., Inc., Rahway, NJ, USA (United States)EME K MazackUnited States Military Academy

Discussion

Member takes

Implication

Supports renin inhibition in experimental renovascular hypertension; leaves open translation to clinical use.

Structured PICO

Does ACHPA-containing renin inhibitory peptide reduce blood pressure similarly to enalaprilat in conscious one-kidney dogs with renal artery constriction?

Population

Conscious one-kidney dogs before and after tightening a renal artery clamp

Intervention

ACHPA-containing renin inhibitory peptide (0.003 to 0.1 mg/kg/min i.v. infusions)

Comparator

Enalaprilat (0.003-0.1 mg/kg i.v. bolus)

Outcome

Blood pressuresurrogate

A novel renin inhibitor is as effective as enalaprilat in reducing blood pressure in a canine model of renovascular hypertension.

Cite This Study

Smith et al. (1987) studied this question.

synapsesocial.com/papers/6a1cc8d5732133fe9885e263 https://doi.org/10.1161/01.hyp.9.2.150

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Comparison of a new renin inhibitor and enalaprilat in renal hypertensive dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of a new renin inhibitor and enalaprilat in renal hypertensive dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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