Why the study?
Does enalaprilat or a renin inhibitor differ in maximal blood pressure reduction in Na-deficient dogs?
Population
14 conscious Na-deficient dogs (5 in first experiment, 9 in second experiment)
Comparison
Enalaprilat followed by statine-containing renin… vs Baseline/control levels and alternate drug…
Design
Preclinical
Authors
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May indicate ACE inhibitor BP effects beyond renin-angiotensin blockade in Na depletion; leaves open clinical translation.
Does enalaprilat or a renin inhibitor differ in maximal blood pressure reduction in Na-deficient dogs?
In Na-deficient dogs, ACE inhibition with enalaprilat provides additional blood pressure reduction beyond maximal renin inhibition, suggesting mechanisms beyond angiotensin II suppression.
Blaine et al. (1985) studied this question.
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