June 1, 1989HypertensionOpen Access

Combined renin and converting enzyme inhibition in rats.

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Why the study?

Does combined renin and converting enzyme inhibition reduce blood pressure and plasma angiotensin II in rats?

Population

Conscious rats (sodium-replete and low sodium diet)

Comparison

Renin inhibitor CP71362 alone or combined with… vs Baseline or enalapril alone

Design

Preclinical

Authors

PMP. F. MentoPfizer (United States)WHWilliam F. HoltAlcon (United States)WMWilliam R. MurphyWichita State University

Discussion

Member takes

Implication

May support dual renin-ACE inhibition in experimental models; leaves open translation to human hypertension.

Structured PICO

Does combined renin and converting enzyme inhibition reduce blood pressure and plasma angiotensin II in rats?

Population

Conscious rats (sodium-replete and low sodium diet)

Intervention

Renin inhibitor CP71362 (100 micrograms/kg/min) alone or combined with chronic enalapril (30 mg/kg/day)

Comparator

Baseline or enalapril alone

Outcome

Mean arterial pressure and plasma renin-angiotensin system parameters (plasma renin activity, plasma angiotensin II)surrogate

Combined renin and converting enzyme inhibition provides additive blood pressure lowering and suppression of angiotensin II in sodium-replete rats.

Cite This Study

Mento et al. (1989) studied this question.

synapsesocial.com/papers/6a7bc481351d91d38cc632cc https://doi.org/10.1161/01.hyp.13.6.741

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Combined renin and converting enzyme inhibition in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Combined renin and converting enzyme inhibition in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider