What question did this study set out to answer?

To compare the effects of angiotensin-converting enzyme inhibition versus renin inhibition on renal and systemic hemodynamics in rats following myocardial infarction.

May 1, 1993Journal of Cardiovascular Pharmacology

Comparison of Angiotensin Converting Enzyme and Renin Inhibition in Rats Following Myocardial Infarction

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Why the study?

Does acute administration of enalapril or CP71362 improve renal and systemic hemodynamics in rats following myocardial infarction?

Population

Rats 1 month after induction of myocardial infarction by ligation of the left coronary artery, and normal…

Comparison

Acute administration of enalapril or CP71362 at… vs Normal control rats and untreated baseline state.

Design

Preclinical

Follow-up

Acute (1 month post-MI)

Authors

PMP. F. MentoPfizer (United States)MMMary E. MaitaPfizer (United States)WMWilliam R. MurphyWichita State University

Discussion

Member takes

Implication

Suggests shared cardiorenal mechanisms for ACE and renin inhibition in rat MI models; leaves open human translation.

Key Points

To compare the effects of angiotensin-converting enzyme inhibition versus renin inhibition on renal and systemic hemodynamics in rats following myocardial infarction.
Assessed systemic and renal hemodynamics in rats one month following myocardial infarction induced via left coronary artery ligation versus normal controls.
Administered acute equihypotensive doses of the ACE inhibitor enalapril or the renin inhibitor CP71362, calibrated to lower mean arterial pressure by 15 mm Hg in normal rats.
Untreated post-infarction rats exhibited an 18% reduction in renal blood flow (p < 0.01), a 14% drop in the fraction of cardiac output perfusing the kidneys (p < 0.01), and elevated renal vascular resistance (p < 0.01).
Both enalapril and CP71362 significantly lowered renal vascular resistance to control levels (p < 0.02) while increasing renal blood flow and kidney perfusion fraction in post-infarction rats.
Both agents were equally effective in reducing elevated left ventricular end-diastolic pressure (baseline p < 0.002 vs control) and total peripheral resistance in post-infarction rats.

Structured PICO

Does acute administration of enalapril or CP71362 improve renal and systemic hemodynamics in rats following myocardial infarction?

Population

Rats 1 month after induction of myocardial infarction by ligation of the left coronary artery, and normal control rats.

Intervention

Acute administration of enalapril (ACE inhibitor) or CP71362 (renin inhibitor) at a dose that lowered mean arterial pressure by 15 mm Hg in normal rats.

Comparator

Normal control rats and untreated baseline state.

Outcome

Renal and systemic hemodynamics (renal blood flow, renal vascular resistance, left ventricular end-diastolic pressure, total peripheral resistance).surrogate

ACE inhibition and renin inhibition have similar beneficial effects on cardiorenal function in a rat model of myocardial infarction, suggesting a shared mechanism of improving renal hemodynamics in congestive heart failure.

Cite This Study

Mento et al. (1993) studied this question.

synapsesocial.com/papers/6a925fe4a10c1849f25efbce https://doi.org/10.1097/00005344-199305000-00016

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Comparison of Angiotensin Converting Enzyme and Renin Inhibition in Rats Following Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Comparison of Angiotensin Converting Enzyme and Renin Inhibition in Rats Following Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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