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July 1, 1994British Journal of PharmacologyOpen Access

Lack of correlation of hypotensive effects with prevention of cardiac hypertrophy by perindopril after ligation of rat coronary artery

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Key result

Perindopril prevented right ventricular hypertrophy without affecting systemic blood pressure in rats with heart failure after coronary ligation (r=0.06 for correlation).

Why the study?

Do ACE inhibitors prevent cardiac hypertrophy independently of blood pressure reduction in rats with heart failure after coronary ligation?

Population

Rats with experimental heart failure following coronary ligation

Comparison

Perindopril or enalapril for three weeks… vs Sham operation and controls subjected to…

Design

Preclinical, Randomly assigned to six groups

Follow-up

3 weeks

Authors

KCKiyoshi ChibaDaiichi-Sankyo (Japan)SMSachiko MoriyamaDaiichi-Sankyo (Japan)YIYutaka IshigaiDaiichi-Sankyo (Japan)

Discussion

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Implication

Does not support clinical adoption; hypothesis-generating for BP-independent ACEI effects on RV remodeling in experimental HF.

Key Points

  • The study aims to determine if the effects of ACE inhibitors on cardiac hypertrophy are independent of blood pressure changes.
  • Animals divided into six groups including controls and different treatment doses of perindopril and enalapril.
  • Chronic treatment lasted three weeks following coronary artery ligation, with weekly measurements of blood pressure.
  • Assessment of cardiac function and hypertrophy through heart weight and ACE activity in various tissues was conducted.
  • Perindopril at 0.2 mg kg-1 day-1 prevented right ventricular hypertrophy without lowering systemic blood pressure.
  • Enalapril at 20 mg kg-1 day-1 reduced both right ventricular hypertrophy and systemic blood pressure.
  • No significant correlation was found between blood pressure and right ventricular hypertrophy with either treatment (r = 0.06 for perindopril and r = 0.1 for enalapril).

Study Design

Type

RCT

Randomization

Randomized

Structured PICO

Do ACE inhibitors prevent cardiac hypertrophy independently of blood pressure reduction in rats with heart failure after coronary ligation?

P
Population
Rats with experimental heart failure following coronary ligation, treated with ACE inhibitors for three weeks.
I
Intervention
Perindopril (0.2 or 2 mg kg-1 day-1) or enalapril (2 or 20 mg kg-1 day-1) for three weeks starting one week after ligation
C
Comparator
Sham operation and controls subjected to coronary ligation without ACE inhibitor treatment
O
Outcome
Cardiac function, heart weight (index of myocardial hypertrophy), and ACE activities in plasma and tissuessurrogate

Perindopril prevents cardiac hypertrophy independently of its hypotensive effects in a rat model of heart failure, suggesting a role for local cardiac ACE activity in hypertrophy progression.

Cite This Study

Chiba et al. (1994) conducted an RCT in Experimental heart failure following coronary ligation. Perindopril or enalapril vs. Sham operation and untreated coronary ligation controls was evaluated on Cardiac function, heart weight (myocardial hypertrophy), and ACE activities. Perindopril prevented right ventricular hypertrophy without affecting systemic blood pressure in rats with heart failure after coronary ligation (r=0.06 for correlation).

synapsesocial.com/papers/6a1fe10dfd96d06e05430dbahttps://doi.org/10.1111/j.1476-5381.1994.tb13155.x
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Also Consider

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