Why the study?
Does perindopril alter angiotensin and bradykinin peptide levels in rats with myocardial infarction?
Does perindopril alter angiotensin and bradykinin peptide levels in rats with myocardial infarction?
In a rat model of myocardial infarction, the beneficial effects of ACE inhibition appear to be mediated by reduced cardiac angiotensin II levels rather than increased tissue bradykinin.
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Findings in rat MI model should not change ACE inhibitor use; leaves open tissue bradykinin contribution in humans.
Duncan et al. (1996) studied this question.
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