Why the study?
Does perindopril alter vascular ACE, AT1 receptor, and NOS expression in patients with ischemic heart disease?
Does perindopril alter vascular ACE, AT1 receptor, and NOS expression in patients with ischemic heart disease?
ACE inhibition with perindopril suppresses vascular ACE and increases eNOS/iNOS expression, but also upregulates AT1 receptors, highlighting complex vascular effects in coronary heart disease.
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Complex vascular effects of perindopril in ischemic heart disease warrant caution; leaves open net clinical impact pending randomized trials.
Zhuo et al. (2002) studied this question.