What question did this study set out to answer?

To determine the distribution and duration of tissue angiotensin-converting enzyme (ACE) inhibition in rats following oral administration of perindopril.

December 1, 1988Journal of Cardiovascular Pharmacology

Effects of Perindopril on Tissue Angiotensin-Converting Enzyme Activity Demonstrated by Quantitative in vitro Autoradiography

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Authors

KSKeiji SakaguchiThe University of Melbourne BJBruce JacksonGlan Clwyd Hospital SCSiew Yeen ChaiSarawak General Hospital

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Implication

Tissue ACE inhibition may explain prolonged ACE inhibitor effects in rats; leaves open its role in chronic human hypotension.

Key Points

To determine the distribution and duration of tissue angiotensin-converting enzyme (ACE) inhibition in rats following oral administration of perindopril.
Administered a single oral dose of perindopril (1 mg/kg) to rats.
Quantified tissue ACE activity across organs using quantitative in vitro autoradiography with [125I]-351A radioligand and assessed plasma ACE activity alongside the pressor response to intravenous angiotensin I.
At 4 hours post-dose, ACE was significantly inhibited in the kidney proximal tubules (24% of control), lung parenchyma (10%), and aortic wall (18%) (p < 0.01), showing only partial recovery at 24 hours (32–63%).
The pressor response to intravenous angiotensin I was inhibited by 95% at 4 hours and remained partially suppressed at 24 hours, despite plasma perindoprilic acid becoming undetectable by 24 hours.

Cite This Study

Sakaguchi et al. (1988) studied this question.

synapsesocial.com/papers/6a75dd74f56d87d9178b6e1a https://doi.org/10.1097/00005344-198812000-00013

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Effects of Perindopril on Tissue Angiotensin-Converting Enzyme Activity Demonstrated by Quantitative in vitro Autoradiography

Discussion

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Implication

Key Points

Cite This Study

Effects of Perindopril on Tissue Angiotensin-Converting Enzyme Activity Demonstrated by Quantitative in vitro Autoradiography

Discussion

Member takes

Implication

Key Points

Cite This Study

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