Why the study?
Does perindopril differentially regulate angiotensin peptide levels in plasma and kidney of rats?
Population
Male Sprague-Dawley rats
Comparison
Perindopril administered in drinking water at… vs Control group
Design
Preclinical
Follow-up
7 days
Authors
Loading...
Demonstrates tissue-specific angiotensin effects of perindopril in rats; leaves open translation to human cardiovascular outcomes.
Does perindopril differentially regulate angiotensin peptide levels in plasma and kidney of rats?
Perindopril demonstrates differential regulation of angiotensin peptides in plasma versus kidney, supporting the concept that ACE inhibitors' cardiovascular effects depend on tissue angiotensin system modulation.
Campbell et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: