What does this research mean for the field?

Oral administration of the ACE inhibitor perindopril readily penetrates the vascular wall to potently and equally inhibit both endothelial and adventitial vascular ACE, reducing both circulating and locally formed Angiotensin II. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the acute and chronic in vivo inhibition of angiotensin-converting enzyme (ACE) by perindopril across endothelial and adventitial vessel layers and major organs.

March 1, 1997Journal of Cardiovascular Pharmacology

Acute and Chronic In Vivo Inhibition of Angiotensin-Converting Enzyme by Perindopril in the Endothelium and Adventitia of Large Arteries and Organs of the Rabbit

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Why the study?

Does perindopril inhibit ACE in the endothelium and adventitia of large blood vessels and organs in a rabbit model?

Population

Rabbit model

Design

Preclinical

Authors

JZJia L. ZhuoTulane University DCDavid CasleyThe Royal Melbourne Hospital CMCarmel MuroneOlivia Newton-John Cancer Wellness & Research Centre

Discussion

Member takes

Implication

Perindopril inhibits vascular ACE in rabbits; hypothesis-generating and requires human validation before clinical consideration.

Key Points

To examine the acute and chronic in vivo inhibition of angiotensin-converting enzyme (ACE) by perindopril across endothelial and adventitial vessel layers and major organs.
Administered acute oral doses (0.1, 0.3, and 1 mg/kg) or chronic oral doses (0.3 mg/kg) of perindopril in rabbits.
Quantified free and total ACE inhibition across the aorta, carotid, and femoral arteries, heart, lung, and kidney using in vitro autoradiography with [(125)I]351A.
Perindopril significantly lowered plasma ACE (p < 0.001), the plasma Ang II/Ang I ratio (p < 0.01), and mean arterial pressure (p < 0.001) in a dose-dependent manner.
Free ACE was inhibited to an equivalent degree in both the endothelium and adventitia of the aorta, carotid, and femoral arteries without altering total vessel ACE.
Vascular and tissue ACE inhibition strongly correlated with plasma ACE and plasma Ang II/Ang I ratios (r = 0.63–0.89, p < 0.001), showing uniform vessel wall penetration across all three large arteries.

Structured PICO

Does perindopril inhibit ACE in the endothelium and adventitia of large blood vessels and organs in a rabbit model?

Population

Rabbit model

Intervention

Perindopril (short-term oral administration at 0.1, 0.3, and 1 mg/kg, or long-term oral administration at 0.3 mg/kg)

Outcome

Inhibition of ACE in endothelium and adventitia of large blood vessels (aorta, carotid, femoral arteries), heart, lung, and kidneysurrogate

Perindopril readily penetrates the vascular wall and potently inhibits both endothelial and adventitial vascular ACE, suggesting a mechanism for inhibiting local Ang II formation.

Cite This Study

Zhuo et al. (1997) studied this question.

synapsesocial.com/papers/6a1e8ac00a6b1b87af954d1f https://doi.org/10.1097/00005344-199703000-00001

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Acute and Chronic In Vivo Inhibition of Angiotensin-Converting Enzyme by Perindopril in the Endothelium and Adventitia of Large Arteries and Organs of the Rabbit

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Acute and Chronic In Vivo Inhibition of Angiotensin-Converting Enzyme by Perindopril in the Endothelium and Adventitia of Large Arteries and Organs of the Rabbit

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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