July 1, 1988Endocrinology

Characterization of Angiotensin Converting Enzyme (ACE) in the Testis and Assessment of thein VivoEffects of the ACE Inhibitor Perindopril

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Population

Rats (tissues evaluated: testis, lung, kidney, aorta)

Design

Preclinical

Authors

BJBruce JacksonGlan Clwyd Hospital RCRose CubelaThe University of Melbourne KSKeiji SakaguchiThe University of Melbourne

Discussion

Member takes

Implication

May reassure on testicular safety of ACE inhibitors; leaves open human translation of tissue selectivity.

Structured PICO

Population

Rats (tissues evaluated: testis, lung, kidney, aorta)

Intervention

Perindopril administered via oral gavage

Outcome

Inhibition of tissue ACE (measured by radioligand binding)surrogate

Perindopril does not penetrate the blood-testis barrier to inhibit testicular ACE, which may explain the absence of testicular adverse effects with ACE inhibitors.

Cite This Study

Jackson et al. (1988) studied this question.

synapsesocial.com/papers/6a798edc7399945d380212eb https://doi.org/10.1210/endo-123-1-50

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Characterization of Angiotensin Converting Enzyme (ACE) in the Testis and Assessment of thein VivoEffects of the ACE Inhibitor Perindopril

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of Angiotensin Converting Enzyme (ACE) in the Testis and Assessment of thein VivoEffects of the ACE Inhibitor Perindopril

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider