Why the study?
Does intravenous perindoprilat improve coronary vasomotor responses to cold pressor test and papaverine in untreated patients with essential hypertension?
Population
10 untreated patients with essential hypertension, no other risk factors, and angiographically normal…
Comparison
Intravenous perindoprilat vs Baseline (before intravenous perindoprilat)
Authors
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May improve acute coronary endothelial function in untreated hypertension; leaves open translation to oral therapy or outcomes.
Does intravenous perindoprilat improve coronary vasomotor responses to cold pressor test and papaverine in untreated patients with essential hypertension?
Intravenous ACE inhibition with perindoprilat acutely restores normal endothelium-dependent coronary vasodilation in patients with recently diagnosed, untreated essential hypertension.
Antony et al. (1996) studied this question.
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