Key result
Chronic administration of perindopril for 2 months increased flow-dependent dilatation and restored flow-dependent increases in radial artery compliance and distensibility (P<0.05).
Why the study?
Does perindopril improve flow-dependent dilatation and radial artery mechanics in stable congestive heart failure patients?
Population
16 stable congestive heart failure patients, who had never been treated with ACE inhibitors
Comparison
Perindopril 4 mg oral once daily for 2 months vs Matching placebo for 2 months
Design
RCT, randomized, double-blind
Follow-up
2 months
Authors
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Perindopril improves vascular function in stable HF; extends ACE inhibitor benefits to arterial mechanics in RCTs.
RCT (n=16)
Double-blind
Randomized
Does perindopril improve flow-dependent dilatation and radial artery mechanics in stable congestive heart failure patients?
p-value: p=<0.05
Chronic ACE inhibition with perindopril improves flow-dependent dilatation and restores the flow-dependent increase in compliance and distensibility of the radial artery in patients with stable heart failure.
Joannidès et al. (2001) conducted an RCT in Congestive heart failure (n=16). Perindopril vs. Placebo was evaluated on Flow-dependent dilatation and radial artery mechanics (compliance and distensibility) at known shear stress levels (p=<0.05). Chronic administration of perindopril for 2 months increased flow-dependent dilatation and restored flow-dependent increases in radial artery compliance and distensibility (P<0.05).
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