What does this research mean for the field?

In chronic heart failure, endothelial dysfunction occurs in small peripheral resistance arteries without structural remodeling, and ACE inhibition prevents this dysfunction while inducing beneficial vascular remodeling. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1996AJP Heart and Circulatory Physiology

Peripheral artery structure and endothelial function in heart failure: effect of ACE inhibition

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Why the study?

Does chronic treatment with perindopril improve endothelial function and vascular structure in a rat model of chronic heart failure?

Population

Rat model of chronic heart failure induced by coronary artery ligation

Comparison

Chronic treatment with the ACE inhibitor… vs Untreated chronic heart failure rats

Design

Preclinical

Follow-up

1 month or 1 year

Authors

PMPaul MulderUniversité Paris-Sud LEL. ElfertakCentre National de la Recherche Scientifique VRVincent RichardKuban State University

Discussion

Member takes

Implication

Supports vascular benefits of perindopril in rat CHF; leaves open translation to human peripheral arteries.

Structured PICO

Does chronic treatment with perindopril improve endothelial function and vascular structure in a rat model of chronic heart failure?

Population

Rat model of chronic heart failure induced by coronary artery ligation

Intervention

Chronic treatment with the ACE inhibitor perindopril

Comparator

Untreated chronic heart failure rats

Outcome

Vasodilatory response to acetylcholine and vascular morphological changes (media cross-sectional area and collagen density) in isolated, perfused femoral and mesenteric artery segmentssurrogate

ACE inhibition with perindopril prevents CHF-induced endothelial dysfunction and induces vascular remodeling in small peripheral arteries in a rat model.

Cite This Study

Mulder et al. (1996) studied this question.

synapsesocial.com/papers/6a1784914f2b3115b012a86a https://doi.org/10.1152/ajpheart.1996.271.2.h469

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Peripheral artery structure and endothelial function in heart failure: effect of ACE inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Peripheral artery structure and endothelial function in heart failure: effect of ACE inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider