March 1, 1997Journal of Cardiovascular Pharmacology
Endothelium-Dependent Relaxation Is Not Uniformly Impaired in Chronic Heart Failure
Structured PICO
P
Population
Rats with heart failure resulting from coronary artery ligation
I
Intervention
Organ-bath experiments assessing endothelium-dependent relaxation using acetylcholine, nitroglycerin, prostaglandin F(2alpha), and N(omega)-nitro-L-arginine (NNA) in segments of pulmonary artery, abdominal aorta, and small mesenteric artery
C
Comparator
Sham-operated control rats
O
Outcome
Endothelium-dependent relaxation and contribution of nitric oxide (NO) productionsurrogate
In a rat model of heart failure, endothelium-dependent relaxation is impaired in the pulmonary artery but not uniformly across other arterial beds, and this impairment is not solely due to defective NO production.
Authors
Discussion
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Implication
Challenges assumption of uniform endothelial dysfunction across arterial beds in experimental HF; leaves open clinical translation and therapeutic implications.
Cite This Study
Baggia et al. (1997) studied this question.