July 1, 1992Cardiovascular Research

Impairment of endothelium dependent responses in a rat model of chronic heart failure: effects of an exercise training protocol

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Why the study?

Does an exercise training protocol improve endothelium-dependent vasodilation in a rat model of chronic heart failure?

Structured PICO

Does an exercise training protocol improve endothelium-dependent vasodilation in a rat model of chronic heart failure?

Population

Female Wistar rats with heart failure produced by coronary artery occlusion (n=10) and sham-operated matched group (n=6).

Intervention

Treadmill exercise schedule for six weeks (started six weeks after recovery from surgery).

Comparator

Non-trained rats with heart failure, and sham-operated animals.

Outcome

Response of aortic rings to endothelium-dependent (acetylcholine) and endothelium-independent (sodium nitroprusside) vasodilating agents measured in an organ bath.surrogate

Chronic heart failure impairs endothelium-dependent vasodilation in a rat model, which is not significantly reversed by a 6-week exercise training protocol.

Discussion

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Implication

Impaired endothelial relaxation in HF rats was unaffected by exercise; leaves open whether training restores vasodilation in chronic heart failure models.

Cite This Study

Lindsay et al. (1992) studied this question.

synapsesocial.com/papers/6a82fbb7445062265a9c8310 https://doi.org/10.1093/cvr/26.7.694

Topics

Heart failure HFrEF treatment

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Implication

Impaired endothelial relaxation in HF rats was unaffected by exercise; leaves open whether training restores vasodilation in chronic heart failure models.