Why the study?
Does congestive heart failure impair endothelium-dependent vasodilation in hindlimb resistance vessels in dogs?
Population
Dogs with and without congestive heart failure induced by continuous rapid ventricular pacing
Comparison
Administration of acetylcholine, adenosine… vs Dogs without heart failure
Design
Preclinical
Authors
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Endothelial impairment in canine HF models; leaves open relevance to human disease and requires clinical translation studies.
Does congestive heart failure impair endothelium-dependent vasodilation in hindlimb resistance vessels in dogs?
Endothelium-dependent vasodilation in hindlimb resistance vessels is impaired in dogs with congestive heart failure, likely due to diminished EDRF/NO production or release.
Ueno et al. (1994) studied this question.
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