Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing‐induced heart failure
Why the study?
Does the endothelium modulate the relaxant effects of nitroglycerin in blood vessels from dogs with pacing-induced heart failure?
Population
Vascular preparations from dogs with and without pacing-induced congestive heart failure
Comparison
Nitroglycerin and acetylcholine vs Endothelium-intact vs endothelium-denuded rings…
Design
Preclinical
Authors
Discussion
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Implication
Challenges endothelium-independent assumption for nitroglycerin in HF models; leaves open translation to human vessels.
Key Points
- To determine whether the relaxant actions of nitroglycerin are modulated by the vascular endothelium in canine models of pacing-induced congestive heart failure.
- Examined isolated ring preparations from four vessels (dorsal pedal artery, saphenous vein, left anterior descending coronary artery, and circumflex coronary artery) in dogs with and without pacing-induced heart failure.
- Evaluated vascular responses to acetylcholine and nitroglycerin in both endothelium-intact and mechanically denuded vessel rings.
- Endothelial removal enhanced nitroglycerin-induced relaxation, significantly reducing the EC50 in most intact vascular rings from both control and heart failure cohorts.
- Maximal heart failure significantly increased nitroglycerin sensitivity in peripheral vessels with intact endothelium, while coronary vessel sensitivity remained unchanged.
- Endothelium-dependent relaxation to acetylcholine remained intact across both cohorts, with coronary arteries consistently demonstrating greater maximal relaxation than peripheral vessels.
Structured PICO
Does the endothelium modulate the relaxant effects of nitroglycerin in blood vessels from dogs with pacing-induced heart failure?
P
Population
Vascular preparations (dorsal pedal artery, saphenous vein, left anterior descending coronary artery and circumflex coronary artery) from dogs with and without pacing-induced congestive heart failure (CHF)
I
Intervention
Nitroglycerin and acetylcholine
C
Comparator
Endothelium-intact vs endothelium-denuded rings; dogs with vs without CHF
O
Outcome
Vascular relaxation response (sensitivity and reactivity)surrogate
Nitroglycerin-induced vascular relaxation is modulated by the endothelium, challenging the previous notion that it is entirely endothelium-independent, particularly in the context of heart failure.
Cite This Study
Förster et al. (1990) studied this question.