Why the study?
Do ANP and BNP have altered vasorelaxing effects on coronary circulation in a canine model of severe heart failure?
Population
Isolated coronary arteries obtained from dogs with severe congestive heart failure induced by rapid right…
Comparison
Atrial natriuretic peptide and brain natriuretic… vs Isolated coronary arteries from control dogs…
Design
Preclinical
Authors
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May limit natriuretic peptide efficacy in severe HF; extends animal evidence of coronary resistance but leaves open human translation.
Do ANP and BNP have altered vasorelaxing effects on coronary circulation in a canine model of severe heart failure?
Severe heart failure blunts the vasorelaxant effects of ANP and BNP in coronary arteries, likely due to downregulation of natriuretic peptide receptors.
Matsumoto et al. (1999) studied this question.
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