What question did this study set out to answer?

This research investigates how the endogenous natriuretic peptide system influences heart and coronary function in congestive heart failure.

November 1, 1997AJP Heart and Circulatory Physiology

Effect of endogenous natriuretic peptide system on ventricular and coronary function in failing heart

Q: What is the clinical evidence from this study?

Population: Congestive heart failure. Intervention: Intracoronary infusion of natriuretic peptide receptor antagonist HS-142-1 and intracoronary BNP vs. Normal dogs / Baseline. Primary outcome: Ventricular and coronary function (LV relaxation, coronary blood flow, LV pressures).

View Full Paper

Ask AI

Bookmark

Key result

Intracoronary infusion of natriuretic peptide receptor antagonist HS-142-1 impaired left ventricular relaxation and decreased coronary blood flow in dogs with chronic heart failure.

Why the study?

Does the intracardiac natriuretic peptide system modulate myocardial and coronary function in congestive heart failure?

Key Points

This research investigates how the endogenous natriuretic peptide system influences heart and coronary function in congestive heart failure.
An intracoronary infusion of natriuretic peptide receptor antagonist HS-142-1 was performed in anesthetized dogs with chronic CHF.
The effects of exogenous BNP were analyzed in both normal and CHF dogs to contrast with receptor blockade effects.
Left ventricular relaxation and coronary blood flow parameters were measured post-infusion.
Low-dose HS-142-1 impaired left ventricular relaxation and reduced coronary blood flow; higher doses worsened relaxation further without changing blood flow.
Exogenous BNP improved left ventricular relaxation with quicker effects and did not affect coronary blood flow in both normal and CHF dogs.

Structured PICO

Does the intracardiac natriuretic peptide system modulate myocardial and coronary function in congestive heart failure?

Population

Anesthetized dogs with chronic congestive heart failure (CHF) and anesthetized normal dogs

Intervention

Intracoronary infusion of the natriuretic peptide receptor antagonist HS-142-1 (low and higher doses) and intracoronary brain natriuretic peptide (BNP)

Outcome

Ventricular and coronary function (left ventricular relaxation, coronary blood flow, and left ventricular pressures)surrogate

The endogenous natriuretic peptide system has an autocrine-paracrine role in modulating left ventricular and coronary vascular function in congestive heart failure.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Highlights potential protective role of endogenous natriuretic peptides in HF; leaves open human translation.

Cite This Study

Yamamoto et al. (1997) studied Congestive heart failure. Intracoronary infusion of natriuretic peptide receptor antagonist HS-142-1 and intracoronary BNP vs. Normal dogs / Baseline was evaluated on Ventricular and coronary function (LV relaxation, coronary blood flow, LV pressures). Intracoronary infusion of natriuretic peptide receptor antagonist HS-142-1 impaired left ventricular relaxation and decreased coronary blood flow in dogs with chronic heart failure.

synapsesocial.com/papers/6a0fa0c48594bc049cf9334d https://doi.org/10.1152/ajpheart.1997.273.5.h2406

Topics

Heart failure HFrEF treatment Cardiomyopathy

View Full Paper

Ask AI

Bookmark

Effect of endogenous natriuretic peptide system on ventricular and coronary function in failing heart

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effect of endogenous natriuretic peptide system on ventricular and coronary function in failing heart

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider