Key result
Pacing-induced heart failure in conscious dogs attenuated endothelium-mediated coronary vasodilation and significantly reduced nitrite production in isolated coronary arteries and microvessels.
Why the study?
Does pacing-induced heart failure alter coronary endothelial function in conscious dogs?
Population
14 mongrel dogs chronically instrumented for measurements of systemic hemodynamics, left circumflex coronary…
Comparison
Left ventricular pacing for 4 weeks to induce… vs Normal hearts
Design
Preclinical
Follow-up
4 weeks
Authors
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Pacing-induced HF model in dogs leaves open whether coronary endothelial changes translate to human HF or guide therapy.
Does pacing-induced heart failure alter coronary endothelial function in conscious dogs?
Pacing-induced heart failure in dogs leads to depressed endothelium-mediated control of the coronary circulation, likely due to decreased nitric oxide production.
Wang et al. (1994) studied Pacing-induced heart failure (n=14). Pacing-induced heart failure vs. Normal hearts / baseline was evaluated on Coronary endothelial function (coronary artery diameter dilation, blood flow, and nitrite production). Pacing-induced heart failure in conscious dogs attenuated endothelium-mediated coronary vasodilation and significantly reduced nitrite production in isolated coronary arteries and microvessels.
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